I have used Dropbox and Adobe Lightroom for years without any apparent conflict. Suddenly, Lightroom would not launch- despite several different tries and after restarts. I contacted Adobe Lightroom support and they did much exploration of items on my computer (iMac with MacOS vers 11.6) without success. I quote their follow-up e-mail:
"Thank you for contacting Adobe Customer Care. Our conversation ended before we were able to reach a resolution. We are following up to let you know we left your case open.
As discussed it might be permission issue as Pictures folder is required by Lightroom Classic to save all its custom and default settings .So its not recommended to be saved under dropbox( network drive) as its not reliable it may work and may gives trouble .
Also we need to give permission of Read and Write to system Library and Pictures folder. so would suggest to contact apple support to have proper way to remove pictures folder along with it settings and folder outside the dropbox and to have permissions to the system Library as well."
Has the Dropbox community encountered this problem? If so, how was it resolved?